Cell Death Dis: RAGE Plays a Cancer-Promoting Role in Lung Cancer

RAGE (late glycoprotein end-product receptor) is a multi-body receptor that is a member of the immunoglobulin superfamilyThe study found that it was associated with physiological stability, development, inflammation and a variety of diseasesIn addition, in various types of malignancies, including prostate, stomach, breast and colon cancer, rage and its ligands are associated with an average increase in expression, which is thought to be associated with metastasis and adverse prognosis of cancerRAGE is constituent expression in normal lung tissue, and expression levels in lung cancer tissue are lowered, while some contrary studies have found that THE RAGE-mediated signal transduction pathway promotes lung cancerTherefore, the role of RAGE in the development of lung cancer has yet to be further studiedin thein the study, researchers tested the effects of RAGE on lung cancer cells by constructing RAGE transscotrophic strains in human lung cancer cell lines A549 and two local lung gland cancer cells, CL1-0 and CL1-5, and further assessed the role of RAGE in the development of lung cancer through transplanted animal modelsstudies have found that expression RAGE inhibits the growth of A549 cellsThe expression of p53-dependent p21CIP1 promotes RAGE-induced growth inhibition by inhibiting the activity of CDK2 kinase and phosphorylation of RB (environcyoma protein)on the other hand, overexpression RAGE can promote the migration, invasion, and interstitial stem cell properties of lung adenocyte cells through the ERK signal transduction pathwayIn addition, transplant tumor experiments have found that RAGE can promote metastasis of lung cancer cells by raising the expression of p21CIP1 and activating changes in ERK and EMT markersfurther study of the role of TAM (tumor-related macrophages) in tumor microenvironment, and the researchers found that both TAM-related marker molecules CD68 and CD163 and angiogenesis-related marker molecule CD31 were expressed in transplant tumor tissue slicesStudies show that RAGE may induce the accumulation of TAM in lung cancer cells to further promote tumor growth in the bodyin general, the study revealed the role of RAGE in tumor growth and metastasis and its associated mechanisms, suggesting that RAGE plays a carcinogenic role in lung cancer