Cell Death Dis: Radish seed extract Sulforaphene may be a new treatment for esophageal cancer.

Esophageal cancer is one of the ten most common cancers in the world, and previous studies have shown that smoking, eating too much hot tea and red meat, poor oral health, and low intake of fresh fruits and vegetables are all associated with esophageal cancer.
the overall prognosis of the disease is not satisfactory because most patients with esophageal cancer are terminally ill at the time of diagnosis and current treatment strategies are limited.
it is urgent to develop more effective treatment strategies.
with cancer-related research, many naturally active substances, such as astratin and resveratrol, have been shown to inhibit a variety of cancers.
, isothion cyanate in cross-flower vegetables has attracted more and more attention.
SFE (Sulforaphene, Lysin) isolated from radish seedsstrong anti-cancer activity.
study found that SFE can inhibit the development of esophageal cancer.
stethotomy showed that SFE was able to induce apoptosis and that cell cycles were stuck in the G2/M phase.
, cell migration and transwell chamber experiments have shown that SFE can impair the ability of esotratic cancer cells to migrate.
chip results showed that the effects of SFE on esophageal cancer cells were associated with SCD (hard lipid coenzyme A desaturation enzyme), CDH3 (calcium mucous protein 3), MAP2K3 (silk rift active protein kinase kinase 3), and GADH45B (growth-stagnating DNA damage induced protein beta).
SCD and CDH3 can promote the metastasis of esophageal cancer by activating the Wnt signaling pathway, while the last two genes are involved in the positive feedback loop of GED45B-MAP2K3-p38-p53, thereby inhibiting the growth of esophageal cancer.
previous study found that GED45B was the target gene for p53, in which researchers confirmed that it could raise the phosphorylation levels of MAP2K3 in esophedic cancer cells, which in turn activated p38 and p53.
SFE can improve the expression level of MAP2K3 and GDD45B and further stimulate the feedback loop to better play the anti-tumor effect.
, these results show that lysinepotential anti-cancer effect and inhibits metastasis and growth of esophageal cancer.
.