Cell Death Dis: Powerful herbal formula SH003 activates the autophagy cell death process for stomach cancer.

Stomach cancer (GC) is one of the most common types of cancer and the third most common cause of cancer worldwide.
cisplatin is a drug used in cancer treatment.
the use of cisplatin in patients remains a concern due to chemotherapy resistance and some potential adverse effects.
addition, many anti-cancer drugs with toxic side effects also kill normal cells, so herbs may be an effective strategy to reduce anti-cancer side effects.
researchers have found that natural compounds extracted from plants and animals may be a new treatment strategy for cancer treatment.
previous studies have found a powerful herbal formula called SH003, with a ratio of 1:1:1 (w/w) jaundice (Am), Ag andfloor (Tk), as herbs with anti-cancer effects such as anti-inflammatory, anti-angiogenesic and anti-tumor effects.
study found that SH003, a herbal preparation, can induce endosurance network (ER) stress by mediating the PERK-ATF4-CHOP signal transducting path.
SH003-mediated endosinonet stress response inhibits G9a (a histone methyl transferase) and activates cell autophagy by reducing the phosphorylation level of STAT3, which starts with the dissociation of Beclin-1 and the Bcl-2/Beclin-1 complex.
expression of PERK and CHOP can inhibit SH003-induced cell death and autophagy activation.
addition, the use of LC3B or p62-specific siRNA or autophagy inhibitor 3-MA to target cell autophagy can also effectively inhibit SH003 induced GC cell death.
interesting is that SH003 in GC is able to induce BNIP3-mediated autophagy cell death under oxygen-deprived and very oxygen-deprived conditions.
addition, these results show that in hypoxia, SH003-induced endocystic network stress response can regulate the autophagy cell death process induced by BNIP3 by inhibiting the STAT3-G9a path pathline.
, SH003 therapy may be an important cancer treatment strategy under hypoxia-mediated chemotherapy resistance.
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