Cell Death Dis: LINC01116 Collected by IL-1 beta glioma proliferation and neutrophils

Glioma is one of the most common intracranial malignanciesGlioblastoma (stage IV glioma) is the most malignant type of glioma, the total survival time of patients is about 14 months, only less than 5% of the confirmed patients live more than 5 yearsTherefore, it is particularly important to understand the molecular mechanism of the onset of glioma and find its prognostic biomarkers and therapeutic targetstumor microenvironment consists of a variety of cell types associated with tumor development, tumor-related neutrophils (TANs) are an important inflammatory leaching cells in tumor microenvironment, which are closely related to tumor developmentHowever, the potential mechanism for the collection of gliomas is still unknownin thein the study, the researchers found a significant increase in the level of expression of LINC01116 in gliomas, which were positively correlated with the malignancy and survival prognosis of tumors in clinical settingsinternal and external sources experiments found that LINC01116 can regulate the occurrence and development of gliomaThe RNA-seq results analysis showed that knocking down LINC01116 affected the expression of IL-1 beta, which in turn promoted the proliferation of gliomas and the collection of neutrophilsIn addition, co-culture experiments with glioma cells and neutrophils have found that the accumulation of TANs can promote tumor proliferation by producing a variety of cytokinesThe mechanism study found that LINC01116 activates the expression of IL-1 beta by collecting the transcription lactation factor DDX5 into the promoter region of IL-1 betaresults show that LINC01116 can promote the proliferation of glioma and neutrophils by regulating the expression of IL-1 beta, which may be a potential new target for glioma treatment and prognosis