Cell Death Dis: Exosomes from interstitial stem cells or treat Parkinson's disease

Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease (AD), leading to motor and cognitive dysfunction in patientsThe prevalence rate is about 1 per cent among people over 60 in industrialized countriesHowever, current clinical treatment can only improve symptoms and does not effectively protect dopamine neuronsTherefore, the search for neuroprotective drugs for PD patients is urgentin recent years, stem cell-related treatments have attracted a lot of attentionNeural stem cells, induced pluripotent stem cells, embryonic stem cells and mesoplasmic stem cells (MSC) have been studied to treat PDHuman umbilical cord-filled stem cells (hucMSCs) are ideal for PD treatment because of their multi-system age differentiation, the feasibility of self-transplantation, its easy access and the absence of ethical problemsAlthough the study found that hucMSC has a neuroprotective effect, its application is still extremely limited due to its uncontrollable differentiation and other reasonsstem cells can communicate intercellularly through the secretion of Exos (exosomes), which is designed to explore whether exos secreted by hucMSC can function in place of hucMSCin this study, researchers successfully isolated and identified hucMSCs and found that they played an important role in 6-OHDA (6-hydroxydopamine) stimulus SH-SY5Y cell proliferation reactions, and that Exos derived from hucMSC was also involved in the processthe effective absorption of Exos by SH-SY5Y cells after 12 hours of culture by purifying and identifying exosomes and marking with PKH 26Exos pretreatment inhibits autophagy-induced apoptosis by promoting 6-OHDA-stimulated SH-SY5Y cell proliferationIn addition, Exos is able to reach the black matter through the blood-brain barrier (BBB), reducing asymmetric rotation induced by aphethane, reducing the loss and apoptosis of the black dopamine neurons, and raising dopamine levels in the striatumthe above results show that hucMSCs-Exos can cross the blood-brain barrier and have the potential to treat Parkinson's disease