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Oral squamous cell carcinoma (OSCC), which is commonly found in the tongue, cheek area, lips, gums and hard palate, is one of the most common forms of head and neck cancer.
the main treatment for OSCC is surgical excision combined with radiotherapy or chemotherapy.
the method is mainly aimed at primary tumors, OSCC metastasis is difficult to treat with traditional surgical methods.
previous studies have found that high levels of EXPRESSION of ASC proteins cause OSCC's lymph nodes to metaseed, but its underlying mechanism remains unclear.
the study revealed that HIF-1 alpha was involved in asC-induced tumor metastasis.
researchers identified 195 genes associated with cellular movement that were highly SAS_ASC in ASC-expressed cells.
in OSCC-Taiwan, an RNA-seq dataset previously reported by researchers, found that 14 of these representative genes were expressed in OSCC tissue.
9 of these 14 genes were also increased in OSCC-TCGA samples.
researchers found that RRAS2, PDGFA and VEGFA were associated with poor overall survival in patients in the OSCC-TCGA data set.
further studies showed that the initiators of these 14 ASC-induced highly expressed genes all contained a binding base sequence of the transcriptional regulator HIF-1 alpha.
in the oxygen state, ASC interacts with and stabilizes HIF-1 alpha in the cytocytes and nuclei.
In the absence of ASC, there was no significant difference in gene and protein expression levels among molecules involved in the HIF-1 alpha pathway (e.g. VHL and PHD2), but the expression levels of HIF-1 alpha-OH in SAS_ASC cells and the ubibinized water levels of HIF-1 alpha were lower than in SAS_con control cells.
treatment of cells using HIF-1 alpha synthesis inhibitor degoxin, the migration and invasive activity of SAS_ASC cells were reduced.
, the results show that the new ASC-HIF-1 alpha regulatory pathrain can promote lymph node metastasis in OSCC, which may be a potential new treatment strategy for OSCC.
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