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Lung cancer, as one of the most common malignant tumors, poses a serious threat to human health.
, lung adenocarcinoma (LAC) has been the most common pathological type, and its incidence continues to surge.
the prognosm of LAC is poor, its five-year survival rate is only about 15%, the five-year recurrence rate is about 30%, and its related molecular mechanisms are still little known.
, it is particularly important to explore the molecular mechanisms of LAC and to find potential therapeutic targets.
CIP1 (human calcium-integrator binding protein 1) is a congener of calcium-tuning proteins that regulate cell adhesion, migration, and differentiation and is thought to act as a cancer gene in many tumor cells.
its role in LAC has yet to be studied.
CIB1 was raised in LAC tissue and cells, and the study related to the patient's adverse prognosis tested the expression level of CIP1 in LAC tissue and its neighboring normal tissue through immunoglostification technology, and analyzed the relationship between the expression level of CIP1 and the patient's clinical pathological characteristics.
the effects of CIP1 on endal-interstational transformation (EMT) of LAC cells, cell migration, and metastasis.
using LS-MS mass spectrometrometography to identify proteins that interact with CIP1.
the ability of LAC to reduce CIP1-induced LAC migration and metastasis by raising CHIP expression was found to have an increase in the expression level of CIP1 in LAC tissue and cell line, and was associated with clinical pathological characteristics and adverse prognosis in patients.
CHIP is a ubiganic E3 connective enzyme that promotes multi-ubidotinization of CIP1 and degrades CIP1 through protease pathways.
addition, the 10th and 65th lysine residues of CIB1 are the ubiquitinization points of CIB1.
found that chip-mediated CIP1 expression levels were critical to inhibiting LAC transfer and migration.
, these results show that CHIP-mediated CIP1 ubibinization regulates the endotion-interstate transformation process and tumor metastasis in LAC.
