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ATP is the universal biological energy "currency" for all living cells and tissues.
ATP is the universal biological energy "currency" for all living cells and tissues.
Conversely, mitochondrial dysfunction can deplete ATP, leading to autophagy, apoptosis (programmed cell death) or necrosis.
ATP depletion therapy may be used as a feasible strategy to target cancer cells.
In this study, the researchers found that the high ATP production of mitochondrial ATP synthase is a new therapeutic target for anti-cancer therapy (especially the prevention of tumor development).
Researchers have found that the high ATP production of mitochondrial ATP synthase is a new therapeutic target for anti-cancer therapy (especially to prevent tumor development).
Increased expression of ATP5F1C protein in lymph nodes
Increased expression of ATP5F1C protein in lymph nodesImportantly, the researchers found that the transfer ability of MDA-MB-231 cells with high ATP levels increased nearly five times.
The components of mitochondrial complex I–V (including ATP5F1C) and markers related to circulating tumor cells (CTC) and metastasis (such as EpCAM and VCAM1) are overexpressed in cells with high ATP levels.
Cells with high ATP levels exhibit multidrug resistance
Cells with high ATP levels exhibit multidrug resistanceIn summary, the results of this study show that mitochondrial ATP depletion is a new type of treatment strategy to prevent cancer metastasis and avoid treatment failure.
Mitochondrial ATP depletion is a new type of treatment strategy to prevent cancer metastasis and avoid treatment failure.
org/10.
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