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Cell Death Differ: arginine methyltransferase PRMT5: a potential therapeutic target for basal-like breast cancer

 Last Update: 2021-05-31
 Source: Internet
 Author: User

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Breast cancer is a common malignant tumor, which seriously threatens women's health.

The basal-like breast cancer (BLBC) subtype is characterized by the expression of basal markers rather than the status of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor 2 (PR).

PRMT5 (Arginine Methyltransferase 5) is also an oncogene associated with a variety of cancers (including breast cancer).

PRMT5 interacts with KLF5 and methylates the latter

Knockout or drug inhibition (PJ-68) PRMT5 can reduce the expression level of KLF5 and its downstream target genes.

PJ-68 inhibits the growth of PRMT5 transplanted tumors

In summary, the results of this study reveal that PRMT5 can prevent its phosphorylation, ubiquitination and degradation by methylating KLF5, thereby promoting the maintenance and proliferation of breast cancer stem cells.

The results of the study revealed that PRMT5 can methylate KLF5 to prevent its phosphorylation, ubiquitination and degradation, thereby promoting the maintenance and proliferation of breast cancer stem cells.

org/10.

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