Cell Death Differ: Abnormal expression of SPAP5 promotes the proliferation of breast cancer cells

Breast cancer, as the most common type of cancer, is one of the leading causes of cancer-related deaths among women worldwide.
based on the expression levels of estrogen-like (ER), progesterone-like (PgR) and ERBB2 (HER2), breast cancer can be divided into several types and exhibit different tumor invasiveness and different responses to treatment.
is well known that miRNA is a short class of non-coding endogen RNA that regulates gene expression by binding to the 3'-UTR region of the target mRNA.
abnormal expression of miRNA promotes the development of cancer.
previous studies have found that miRNA can be used as a regulatory factor for the development of breast cancer and is associated with the state of hormones.
is over-expressed in breast cancer tissue, and the negative correlation with miR-10b-3p SPAG5 (sperm-related antigen 5) is an important part of the silky schizophrenic spindle in the later stages of the cell cycle.
SPAG5 has been identified as an important proliferative marker and predictive target for chemotherapy sensitivity, playing a role in cancer-causing genes in a variety of cancer types, including triple-negative breast cancer.
that YAP signals and SPAG5 are independent prognostic factors for disease-specific survival in breast cancer patients, the researchers found that SPAG5 was a direct target for miR-10b-3p.
two large breast cancer patients, the abnormally high expression of SPAG5 was associated with poor disease-free survival.
knocking out SPAG5 can seriously damage the cell cycle process, cell proliferation, and cell migration of cancer cells.
relevant model diagram is interesting: in breast cancer patients, the high expression of SPAG5 is accompanied by the activation of the YAP/TAZ signal.
further studies have shown that knocking out YAP, TAZ, and TEAD can significantly reduce the level of expression of SPAG5 and its carcinogenic effects.
YAP, TAZ co-activation factors and TEAD transcription factors are key components of hippo signaling pathps involved in tumor development and metastasis.
addition, the researchers confirmed that SPAG5 was a direct transcription target for TEAD/YAP/TAZ, while pharmacologically targeted YAP and TAZ significantly reduced the level of expression of SPAG5.
all, the findings reveal a cancer-causing feedback loop, including miR-10b-3p, SPAG5, and YAP/TAZ/TEAD, which also promotes abnormal proliferation of breast cancer.
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