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On January 21, 2022, Zhang Haibing's research group from Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences published online in the international academic journal Cell Death and Differentiation entitled "Caspase-8 auto-cleavage regulates programmed cell death and collaborates with RIPK3/MLKL to "prevent lymphopenia" research results
Necroptosis is a form of pro-inflammatory cell death regulated by the cascade phosphorylation of the kinases RIPK1/RIPK3
Caspase-8 is an aspartate-specific cysteine protease that was originally identified as the initiating protein of the apoptotic pathway
In this study, the researchers first found that the self-cleavage of caspase-8 was inductively enhanced under the stimulation of programmed cell necrosis, so it was inferred that the self-cleavage of caspase-8 might be involved in the regulation of programmed necrosis
In conclusion, this study found that caspase-8 disrupted the stability of death complex II through self-cleavage, thereby inhibiting the occurrence of programmed cell necrosis
Zhang Haibing, a researcher from the Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, is the corresponding author of the paper.
Article link: https://pubmed.
