Cell: Clinical studies have confirmed that vaccination of card seedlings can reduce respiratory infections by 75% in older adults.

September 3, 2020 /--- BCG vaccine has a wide range of stimulating effects on the immune system.
makes it effective in preventing infections -- and possibly coVID-19.
new research is investigating this.
card seedlings are often used in children, but in a new double-blind randomized clinical study calledACTIVATE, researchers from research institutions such as Radburg University Medical Center in the Netherlands and the University of Athens in Greece have found that older people can also benefit from card-based seedlings.
results were published online August 31, 2020 in the journal Cell, under the title "ACTIVATE: Randomized clinical trial of BCG ingest in the oldly."
images from CC0 Public Domain.
at Radburg University Medical Center, Mihai Netea, a professor of experimental medicine, is studying the protective effects of card-based seedlings on a variety of infections, known as "trained immunity."
Two years ago, we started the ACTATE study to see if vaccinations protect vulnerable older people from infection, " says Professor Netea.
65-year-olds were randomly vaccinated with a card seedling or placebo upon discharge.
we followed them for a year to see if the card-like seedlings could protect them from a wide range of infections.
" study began before the COVID-19 pandemic and began before the new coronavirus SARS-CoV-2 pandemic.
198 elderly people were injected with placebos or card seedlings when they were discharged from the hospital.
follow-up was originally scheduled for August 2020, but the researchers published their preliminary results due to the arrival of COVID-19.
difference in protective effects: in the placebo group, 42.3 percent of the elderly had an infection, while only 25 percent of the older people in the caesogroup had an infection.
also took longer: participants who were vaccinated with card-mediated seedlings (i.e., card-mediated seedlings) did not develop their first infection until an average of 16 weeks after vaccination, up from 11 weeks in the placebo group.
there was no difference in side effects between the two groups.
Professor Evangelos J. Giamarellos-Bourboulis, author of the paper and author of the paper and a fourth department of internal sciences at attikon University Hospital in Greece, said, "In addition to the obvious effect of card-based seedlings on general infections, the most important observation is that card-based seedlings primarily protect respiratory infections."
75 per cent fewer respiratory infections than 20,000 people who were given a placebo.
" it is not clear whether it is effective against the new coronavirus Although most of the protective effects appear to be for respiratory infections (most likely viral respiratory infections), due to the low incidence of COVID-19 in this study, whether the card is also effective against COVID-19 has not been confirmed.
study does confirm that it is safe to vaccinate older people against a variety of infections.
several studies are currently under way to study the effects of card seedlings on COVID-19.
only these follow-up studies can determine whether vaccination can also prevent new coronavirus infections.
(bioon.com) Reference: 1. Evangelos J. Giamarellos-Bourboulis et al. ACTIVATE: Randomized Clinical Trial Of BCG Ingest AgainSt In The Elderly. Cell, 2020, doi:10.1016/j.cell.2020.08.051.2.Elderly people protected againstst hospitality by BCG vaccine.