Cell: an interorgan neural circuit that suppresses appetite

Cell [IF:4582] ① GLP-1 is released after activation of L cells in the distal ileum of mice, resulting in significant gastric distension and decreased appetite; ② GLP-1R-expressing myenteric neurons in the ileum can sense local GLP-1 and project signals remotely The celiac sympathetic ganglion (CG) regulates gastric motility; ③ After the noradrenergic neurons in the CG are activated, regulating the motor neurons expressing Nos1 (but not ChAT) in the stomach can also cause decreased gastric motility and gastric motili. Dilation; ④ The spinal dorsal root nerve (not the vagus nerve) can sense gastric dilatation, and transmit signals through the lateral reticular nucleus of the medulla to the parathalamic nucleus of the hypothalamus, thereby regulating the brainstem motor nervous system and reducing feedi. An inter-organ neural circuit for appetite suppression 06-02, doi: 11016. ce. 2020007 [Editor's comment] Glucagon-like peptide-1 (GLP-1) is a brain Intestinal peptide, GLP-1 can inhibit gastric emptying, reduce bowel motility, help control food intake and reduce weig. However, GLP-1 secreted by the gut is rapidly degraded and inactivated in the blood circulati. Therefore, how GLP-1 secreted in the lower gut regulates distal organs still needs to be further explor. Recently, a team from Mount Sinai School of Medicine in New York published the latest research in Ce. Using optogenetic and chemical genetic techniques, L cells in the ileum of mice were activated to release GLP-1, which mediates the reduction and inhibition of gastric motility through the abdominal sympathetic gangl. ingesti. Further exploration found that dorsal root neurons located in the spinal cord can sense gastric expansion and transmit sensory signals to the medulla oblongata, thereby regulating the brainstem motor nervous system and reducing feedi.   Disclaimer: This article only represents the author's personal opinion and has nothing to do with China Probiotics Netwo. Its originality and the text and content stated in the text have not been verified by this site, and this site does not make any guarantee or commitment to the authenticity, completeness and timeliness of this text and all or part of its content and te. Readers are only for reference and please Verify the relevant content yourse. Copyright Notice Some articles reproduced on this site are not original, and their copyright and responsibility belong to the original auth. All reprinted articles, links and pictures on this website are for the purpose of conveying more information, and the source and author are clearly indicat. Media or individuals who do not wish to be reprinted can contact us for infringing information that can provide sufficient eviden. , bio149 will be deleted within 12 hours after confirmati. Users are welcome to submit original articles to 86371366@. com, which will be published on the homepage after review, and the copyright and responsibility of the articles belong to the send.

Cell
① GLP-1 is released after activation of L cells in the distal ileum of mice, resulting in significant gastric distension and decreased appetite; ② GLP-1R-expressing myenteric neurons in the ileum can sense local GLP-1 and project signals remotely The celiac sympathetic ganglion (CG) regulates gastric motility; ③ After the noradrenergic neurons in the CG are activated, regulating the motor neurons expressing Nos1 (but not ChAT) in the stomach can also cause decreased gastric motility and gastric motili.

Dilation; ④ The spinal dorsal root nerve (not the vagus nerve) can sense gastric dilatation, and transmit signals through the lateral reticular nucleus of the medulla to the parathalamic nucleus of the hypothalamus, thereby regulating the brainstem motor nervous system and reducing feedi.

An inter-organ neural circuit for appetite suppression 06-02, doi: 11016.

ce.

2020007 [Editor's comment] Glucagon-like peptide-1 (GLP-1) is a brain Intestinal peptide, GLP-1 can inhibit gastric emptying, reduce bowel motility, help control food intake and reduce weig.

However, GLP-1 secreted by the gut is rapidly degraded and inactivated in the blood circulati.

Therefore, how GLP-1 secreted in the lower gut regulates distal organs still needs to be further explor.

Recently, a team from Mount Sinai School of Medicine in New York published the latest research in Ce.

Using optogenetic and chemical genetic techniques, L cells in the ileum of mice were activated to release GLP-1, which mediates the reduction and inhibition of gastric motility through the abdominal sympathetic gangl.

ingesti.

Further exploration found that dorsal root neurons located in the spinal cord can sense gastric expansion and transmit sensory signals to the medulla oblongata, thereby regulating the brainstem motor nervous system and reducing feedi.

---

Cell
① GLP-1 is released after activation of L cells in the distal ileum of mice, resulting in significant gastric distension and decreased appetite; ② GLP-1R-expressing myenteric neurons in the ileum can sense local GLP-1 and project signals remotely The celiac sympathetic ganglion (CG) regulates gastric motility; ③ After the noradrenergic neurons in the CG are activated, regulating the motor neurons expressing Nos1 (but not ChAT) in the stomach can also cause decreased gastric motility and gastric motili.

Dilation; ④ The spinal dorsal root nerve (not the vagus nerve) can sense gastric dilatation, and transmit signals through the lateral reticular nucleus of the medulla to the parathalamic nucleus of the hypothalamus, thereby regulating the brainstem motor nervous system and reducing feedi.

An inter-organ neural circuit for appetite suppression 06-02, doi: 11016.

ce.

2020007 [Editor's comment] Glucagon-like peptide-1 (GLP-1) is a brain Intestinal peptide, GLP-1 can inhibit gastric emptying, reduce bowel motility, help control food intake and reduce weig.

However, GLP-1 secreted by the gut is rapidly degraded and inactivated in the blood circulati.

Therefore, how GLP-1 secreted in the lower gut regulates distal organs still needs to be further explor.

Recently, a team from Mount Sinai School of Medicine in New York published the latest research in Ce.

Using optogenetic and chemical genetic techniques, L cells in the ileum of mice were activated to release GLP-1, which mediates the reduction and inhibition of gastric motility through the abdominal sympathetic gangl.

ingesti.

Further exploration found that dorsal root neurons located in the spinal cord can sense gastric expansion and transmit sensory signals to the medulla oblongata, thereby regulating the brainstem motor nervous system and reducing feedi.

---

Cell[IF:4582]① GLP-1 is released after activation of L cells in the distal ileum of mice, causing significant gastric distension and decreased appetite; ② GLP-1R-expressing myenteric neurons in the ileum can sense local GLP-1 , projecting signals to the celiac sympathetic ganglia (CG) remotely to regulate gastric motility; ③ After the activation of noradrenergic neurons in the CG, regulating the motor neurons expressing Nos1 (but not ChAT) in the stomach can also trigger Decreased gastric motility and gastric distension; ④ The spinal dorsal root nerve (but not the vagus nerve) can sense gastric distension and transmit signals through the lateral reticular nucleus of the medulla to the parathalamic nucleus of the hypothalamus, thereby regulating the brainstem motor nervous system and reducing feedi.

An inter-organ neural circuit for appetite suppression 06-02, doi: 11016.

ce.

2020007 [Editor's comment] Glucagon-like peptide-1 (GLP-1) is a brain Intestinal peptide, GLP-1 can inhibit gastric emptying, reduce bowel motility, help control food intake and reduce weig.

However, GLP-1 secreted by the gut is rapidly degraded and inactivated in the blood circulati.

Therefore, how GLP-1 secreted in the lower gut regulates distal organs still needs to be further explor.

Recently, a team from Mount Sinai School of Medicine in New York published the latest research in Ce.

Using optogenetic and chemical genetic techniques, L cells in the ileum of mice were activated to release GLP-1, which mediates the reduction and inhibition of gastric motility through the abdominal sympathetic gangl.

ingesti.

Further exploration found that dorsal root neurons located in the spinal cord can sense gastric expansion and transmit sensory signals to the medulla oblongata, thereby regulating the brainstem motor nervous system and reducing feedi.

---