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In the chaotic battle of the "All-Can-CAR" technology represented by CAR-T, it is not only the accuracy of the target that competes, but also the core of the T cell's efficacy: high-resolution targets and the enhancement of T cell toxicity, these two elements are indispensable
(1) Auxiliary signal of T cell activation: Anti-CD28 can strengthen the proliferation and activation effects of PHA, ConA, anti-CD2McAb, anti-CD3McAb, etc.
(2) The natural ligand of CD28 is the B cell activated antigen B7/BB1 (CD80), and the combination of CD28 and CD80 is the main way for T-B cells to cooperate with each other and stimulate B cell activation
Her2/CD3× the role of CD28 trispecific antibodies in immune activation in vitro
|
The article number |
The product name |
|
GMP-TL101 |
Anti-human CD3 monoclonal antibody |
|
GMP-TL102 |
Anti-human CD28 monoclonal antibody |
|
GMP-TL503 |
Anti-human HER-2 monoclonal antibody |
|
GMP-TL601 |
CD3/CD28 monoclonal coupling beads |
|
GMP-TL777 |
Recombinant human IL-2 protein (highly effective type) |
|
GMP-TL665 |
Recombinant human CD19 protein |
[3] Trispecific antibodies enhance the therapeutic efficacy of tumor-directed T cells through T cell receptor co-stimulation；
Qun Luo, Ming Lü, Ming Yu, Yan Li, Synergistic stimulation of anti-CD28 antibodies enhanced anti-CD3 antibodies in vitro activation of T lymphocytes and reduced expression of TGF-β.
[5] Trickett A, Kwan YL.
[6] Seung E, Xing Z,Wu L,etc.
