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Can't stop drinking for a long time? Probably "controlled" by this neuron!

 Last Update: 2022-11-01
 Source: Internet
 Author: User

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, it turns out that wanting to drink is "forced".
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.
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Executive summary

On October 4, 2022, a study published in the journal Molecular Psychiatry identified for the first time the neural circuits in the brain that control long-term alcohol consumption
.
Targeting the 5-HT_1A autoreceptor in the midsuture nucleus with agonists may be an innovative pharmacological treatment strategy to address alcohol abuse
.

Research literature

Right now

Professor Bartlett of Queensland University of Technology in Australia said:

Alcohol dependence is a very serious problem in Australia, with 1 in 4 people aged 18 and over exceeding guideline standards in 2020-2021;
The mechanisms driving long-term alcohol dependence in the brain are unknown, and there are few effective treatment options
.

First author Dr.
Belmer said:

The use of drugs that specifically target specific parts of the brain may be a new strategy to combat alcohol abuse;
In this study, by using new drugs, we identified specific_5-HT1A receptors that mediate drinking behavior;
We demonstrate that inhibiting the transmission of serotonin to this receptor reduces alcohol consumption;
Our previous studies in mice showed that taking anti-anxiety drugs daily for 2 weeks could reverse alcohol abuse at 15 weeks
.

conclusion

The study found:

Stimulation of the_5-HT1A autoreceptor in the middle suture nucleus reduces alcohol consumption.
The dorsal and middle suture nucleus_5-HT1A autoreceptors mediate ethanol consumption
after short- and long-term exposure to alcohol, respectively.
Inhibition of 5-HT neuronal activity in the dorsal and middle suture nucleus by chemogenetic means reduces short-term and long-term alcohol consumption
, respectively.
Long-term alcohol intake can alter the 5-HT nerve innervation
in the DG region of the lower layer of the hippocampal dentate gyrus in an autoreceptor-dependent manner by 5-HT_1A.
5-HTMRN→DG neural circuits regulate long-term alcohol intake
.

prospect

Professor Bartlett said: "
We know that alcohol has a great deal of damage to both neurons-brain cells, so the research team will continue to work on new alcohol abuse and addiction treatment strategies, with a focus on understanding how to improve neuroplasticity to restart brain health and physical and mental health
.

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