Candida albicans promotes the progression of oral squamous cell carcinoma in vivo and in vitro

Oral squamous cell carcinoma (OSCC) and oral cavity

Candida albicansInfection, but it is not clear whether the fungus promotes the occurrence and development of oral squamous cell carcinoma, or whether the cancer promotes the growth of fungi

Oral squamous cell carcinoma (OSCC) is a serious health problem worldwide, accounting for 2%-4% of all cancer cases

Approximately 90% of oral tumors are squamous cell carcinoma (OSCC) (1)OSCC is the 16th most common cancer in the world (2) The U.

Is a yeast that is ubiquitous in the mouth (11–13) Proliferate and invade the host mucosal tissue when the epithelial barrier is dysfunctional or destroyed

15–19It is worth noting that the amount and diversity of yeast carried by patients with oral cancer are higher than that of healthy people, and the colonization rate of oral fungi on the surface of tumor epithelium in patients with oral squamous cell carcinoma is higher than that of neighboring healthy people (20–24In addition, persistent oral candidiasis has been observed to lead to the development of oral squamous cell carcinoma in elderly patients (25) Some other studies have shownCandidaInvasion promotes epithelial hyperplasia without treatmentCandidaEpithelial lesions may become abnormally proliferative and transform into cancer (Reference Review25and26) Therefore, there is strong evidence to supportCandidaPromote oral carcinogenic events (16,27–30)but,CandidaInfections in cancer patients may also be considered as the result of altered immune status, because both bone marrow suppression and mucositis can lead to the development of oral candidiasis (8,9,31,32).

CandidaPromote the development and progress of OSCC
.
usein vitroTwo morein vivoModel and we concludeC.
Candida albicansCan promote and enhance the carcinogenic mechanism of oral cancer
.