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With the use of certain tyrosine kinase inhibitors (TKIs) for the treatment of chronic myeloid leukemia (CML), these drugs are also associated with some short- and long-term toxicities, and cardiovascular complications are increasingly being reported
.
A foreign research team described the characteristics and mechanisms of NET formation in CML, and assessed the effects of TKIs on NET formation in vitro and in vitro
With the use of certain tyrosine kinase inhibitors (TKIs) for the treatment of chronic myeloid leukemia (CML), these drugs are also associated with some short- and long-term toxicities, and cardiovascular complications are increasingly being reported
Neutrophils isolated from CML-naïve patients compared with matched controls at baseline and after stimulation with ionomycin (IO) and phorbol 12-myristate 13-acetate (PMA) The cells showed a marked increase in NET formation
Figure 1: Increased neutrophil NETs in CML patients
Figure 2: Ponatinib enhances NET formation in neutrophils from CML patients
Figure 3: BCR-ABL1-transduced ER-HoxB8 cell line system recapitulates CML, TKI effects and reveals PAD4-dependent NET phenotype
Pretreatment of neutrophils with TKIs is associated with differential effects on NET formation, BCR-ABL1 retrovirally transduced HoxB8 immortalized mouse hematopoietic progenitor cells differentiated into neutrophils in vitro showing H3cit and myeloperoxidation Biomass enzyme (MPO) expression was increased, which was consistent with excess NET formation
In conclusion, this article HoxB8 BCR-ABL1 -HoxB8
Original source:
Telerman, A.
Telerman, A.
; Granot, G.
; Leibovitch, C.
; Yarchovsky-Dolberg, O.
; Shacham-Abulafia, A.
; Partouche, S.
; Yeshurun, M.
; Ellis, MH; Raanani, P.
; Wolach, O.
Neutrophil Extracellular Traps Are Increased in Chronic Myeloid Leukemia and Are Differentially Affected by Tyrosine Kinase Inhibitors.
Cancers 2022 ,14 , 119.
https://doi.
org/10.
3390/cancers14010119 Leave a comment here
