Cancer Res: why does breast cancer metastasize? It's probably the microbes in the gut!

June 13, 2019 / Biovalley / a new study from the University of Virginia Cancer Center shows that unhealthy, inflamed intestines can make breast cancer more aggressive and spread to other parts of the body faster Dr Melanie Rutkowski, of the Department of Microbiology, immunology and cancer biology at the University of Virginia, found that destroying the microbiome in mice can make hormone receptor positive breast cancer more aggressive Changing the microbiota, which lives in the gut and other places, has a huge impact on the human body and promotes the spread of cancer Source: http://cn.bing.com she said: "when we take antibiotics to rats for a long time to break the balance of their microbial population, it will lead to systemic and inflammation in breast tissue In this inflamed environment, tumor cells are more likely to spread from tissue to blood and lungs, which are the main site of hormone receptor positive breast cancer metastasis "Hormone receptor positive in most breast cancers - 65% or more - hormone receptor positive This means that their growth is driven by hormones such as estrogen or progesterone The good news is that these types of cancer may respond well to hormone therapy Predicting whether this type of cancer will spread from the breast to other parts of the body (a process called metastasis) is a major challenge in this field, driven by clinical features at the time of diagnosis Rutkowski explained that early metastasis is influenced by many factors "One of them is that there is a high level of immune cells in the tissue called macrophages," she said It has also been shown that the increase of structural protein collagen in tissues and tumors will also lead to the increase of breast cancer metastasis "If you have an unhealthy microbiome before you get breast cancer, both are increasing, and the impact is strong and lasting "Destroying the microbiota can lead to long-term inflammation of tissues and tumor environments," Rutkowski said "These findings suggest that the presence of unhealthy microbiota, as well as changes in tissues associated with unhealthy microbiota, may be an early predictor of invasive or metastatic breast cancer Finally, based on these findings, we speculate that unhealthy microbiota will increase the incidence of invasive and metastatic diseases "Rutkowski, a healthy microbiome, uses powerful antibiotics to destroy the natural gut bacteria of mice, but she stresses that antibiotics are not dangerous and should not be avoided by breast cancer patients or anyone who needs antibiotics to treat infections After all, mice are not human beings, and more research is needed to determine whether there is a link between long-term antibiotic use and cancer outcomes In this study, antibiotics are just a means to an end, a simple way to create a long-term imbalance for the microbiota, similar to the long-term unhealthy microbiota that individuals may experience This kind of effect is far more serious than the effect of a person's normal use of antibiotics, or even multiple use of antibiotics Thanks in part to Rutkowski's research, doctors may eventually be able to manipulate the microbiota to benefit breast cancer patients But Rutkowski said the key message now is the importance of a healthy microbiome There is increasing evidence that a healthy microbiome is essential to many aspects of health Rutkowski is a cancer researcher, not a doctor She noted that some practices to promote healthy microbiota were generally accepted "A healthy diet, high fiber, exercise, sleep - all of which contribute to good health," she said If you do all this, in theory, you should have a healthy microbiome We believe that this is closely related to the long-term beneficial outcome of breast cancer "Relevant research results are published in the Journal of cancer research Reference: Claire buchta rosean et al, pre existing common Dysbiosis a host internal regulator of tissue information and more cell separation in hormone receiver position burst cancer, cancer research (2019) Doi: 10.1158/0008-5472.can-18-3464