Cancer Res: Shocked! Cancer cells can make blood vessels resistant to chemotherapy!

, July 2, 2020 /PRNewswireBiogus,200 (UPI) -- Scientists and collaborators at Hokkaido University have discovered how changes in inflammation caused by chemotherapy intumorcan trigger vascular abnormalities and lead to adverse prognosis in cancer patientsThrough mouse experiments, the team also found that combining an inhibitor could make chemotherapy more effectivechemotherapy is commonly used to treat non-surgical cancers, such as locallate and metastasis casesTherefore, it is essential to clarify drug resistance treatment, which is a major factor leading to malignancy and metastasis of cancertumor blood vessels play an important role in the development of tumors because they deliver nutrients and oxygen to the tumor and act as a means of tumor metastasisTumor vascular endothelial cells (tumor endothelial cells, TEC) are generally considered non-resistantHowever, several years ago, the team's mouse experiments showed that TEC can obtain a variety of abnormal properties, suggesting that blood vessels and cancer cells can promotetumorsresistantFor example, the team confirmed for the first time that intravascular TEC has a resistance to yewol, a second-line chemotherapy drug for urethra cancer, because ABCB1's expression pumps the drug out of the blood vesselimages from Kikuchi H., et al., Cancer Research, June 15, 2020
how many unknowns remain about how human blood vessels are involved in cancer resistanceto help solve the mystery, the team first analyzed samples oftumor
tissue in patients with skin cancer in the urethra before and after receiving first-line chemotherapyThey found that more than 60 percent of patients who received chemotherapy had increased ABCB1 expression in their blood vessels, and that their prognosis was worse than in patients with the same abcB1 expression after treatmentin addition,, they analyzed TEC in blood vessels and bladder cancer cells to study how chemotherapy affects ABCB1 expressionThe results showed that the increase in interleukin-8 (IL-8) secretion in cancer cells after chemotherapy led to changes in inflammation and increased the expression of ABCB1 in THE TECIn another experiment, the newborn blood vessel formation in the urine cancer mice administered by ABCB1 inhibitors in combination with yew alcohol inhibited, inhibiting thetumorto the lungs"Our study provides the first evidence in humans that changes in inflammation intumorlead to resistance in cancer blood vessels," said Kyoko Hida of Hokkaido University, who led the studyThese findings may help to design new treatment strategies, such as the development of inhibitors for ABCB1 and IL-8 to curb drug resistance and improve prognosis" (biovalleybioon.com)reference:Cancer cells make blood vessels drugy rye rye ryeHiroshi Kikuchi et al.
Mrochy-induced IL-8 upregulates MDR1/ABCB1 in thoro edrych sydd yn uny, outcome Cancer Research (2020) DOI: 10.1158/0008-5472.CAN-19-3791