Cancer Res: Identifying specific key proteins that promote the spread of epithelial cell carcinoma

, July 8, 2020 /PRNewswire/ -- Cancer is complex and unpredictable, and although cancer patients can be successfully treated and remission for several years, cancer patients are still at risk of relapse, usually in the form of cancer metastasis, i.ethe cancer cells that remain in the body spread to other sites and continue to growIn a recent study published in the international journalCancer Research, scientists from institutions such as the Moffitt Cancer Research Center identified key proteins that promote the spread of epithelial cell carcinomaPicture Source: CC0 Public Domain
In the article, researchers understand the events that occur at the molecular level of cancer, or can help develop new potential strategies to inhibit and treat cancer metastasis, and say the special protein can be regulated by microRNA to cause fluctuations in its expression, which can help spread the cancer to distant organs, called DeltaNp63, a member of the tumor-suppressing gene p53 familyresearchers aim to develop new treatments for p53 mutant cancers, which are difficult to target because of their wide range of important cellular functionsIn the study, the researchers expanded previous studies on the p53 family and its ability to inhibit tumor growth and development, and said that members of the deltaNp63 and p53 family can regulate the epithelial interstitial transformation process (EMT), in which cancer cells can promote the loss of host cells Contact with surrounding tumor cells, which enter the bloodstream and spread to other parts of the body, overexpresses in many primary tumors and metastatic cancers, and the researchers believe that deltaNp63 must be silent to go through the EMT process and enter the bloodstream to begin to spreadin order to better understand the expression of the deltaNp63 protein and its key role in the cancer metastasis process, the researchers developed a mouse model to regulate the expression of deltaNp63 protein during breast cancer metastasis, and found that the periodic expression of the protein is necessary for the effective diffusion of cancer cells, in addition to the researchers also found four networks of microRNAs, which can be regulated by TGF beta, which can be targeted and silentresearcher Flores said the findings are important because they help us to study the regulatory mechanisms of deltaNp63 and TGF beta, which are important players in the cancer metastasis process, and P53, which often occurs in human cancers, and researchers have found that deltaNp63 and p53 can interact extensively in cancer, so researchers can use this information to develop individualized therapies that change the p53/p63 pathwayResearchers are currently developing microRNA-based therapies to ensure that proteins such as deltaNp63 are expressed at the right level in growing cancers, blocking the spread of cancer metastasis(BioValleyBioon.com)original origin:Ngoc H.BBui, Marco Napoli, Andrew John Davis, et al.,Spatiotemporal Regulation of Np63 by TGF beta-Regulated miRNAs I Essential for Cancer Metastasis,Cancer Research(2020)doi: 10.1158/0008-5472.CAN-19-2733