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Researchers at Baylor School of Medicine, the MIT Broad Institute, and Harvard University, as well as clinicians at Washington University in St.
"TNBC is one of the most difficult breast cancers to treat, and standard treatments require multiple chemotherapy drugs and unfortunately often fail to cure patients," said
Using an innovative analytical method called "Microscale Protein Genomics" (Satpathy et al, 2020), the research team analyzed tumor biopsies
"Proteomic analysis of pretreatment biopsies uniquely reveals metabolic pathways associated with treatment resistance, including fatty acid metabolism," said Anurag, who is also a member of
The team then performed analysis
"In other cancer types, the loss of LIG1 has also been associated with a poor prognosis, suggesting that this deletion has broader clinical implications," Anurag said
Dr Matthew Ellis is a McNair Scholar at Baylor University and director of the Lester and Sue Smith Breast Center.
LIG1 is a key component
"This is an exciting result that demonstrates the close collaboration
Proteogenomic markers of chemotherapy resistance and response in triple negative breast cancer
