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Cancer Cell: Lung cancer fibroblasts influence the patient's response to treatment

 Last Update: 2021-11-02
 Source: Internet
 Author: User

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The current personalized cancer treatment paradigm is mainly based on the molecular characteristics of cancer cells, such as cancer-causing mutations

CAFs constitute a large part of the tumor microenvironment and are considered to be an important part of the cancer ecosystem

NSCLC breast cancer pancreatic cancer

The lack of a comprehensive understanding of the functional heterogeneity of CAFs hinders the development of more personalized cancer treatments, and previous studies based on various CAF definitions have also produced inconsistent results

Three subtypes of lung cancer fibroblasts define different treatment paradigms

The three subtypes of lung cancer fibroblasts define different treatment paradigmsThe three subtypes of lung cancer fibroblasts define different treatment paradigms

Recently, researchers have established a living biobank of CAFs from living tissues of patients with non-small lung cancer (NSCLC) , including a broad molecular spectrum of CAFs in clinical NSCLC

Researchers have established a living biobank of CAFs from living tissues of patients with non-small lung cancer (NSCLC).

This CAF function classification is related to the patient's clinical response to targeted therapy, and is also related to the tumor immune microenvironment.

Original source:

Haichuan Hu et al.

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