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A recent study explains how chemical modifications of messenger RNA, or so-called epigenetics, that alter the genetic material of a particular type of leukemia cell cause highly proliferating leukemia cells to transform into normal cells that can no longer reproduce
The study, published in the journal Leukemia, is by Alberto Bueno-Costa, a researcher in Dr.
Cancer is a condition in which healthy cells become malignant cells with entirely new characteristics, such as the ability to divide uncontrollably
"We know that one strategy for human tumors to evade the effects of drugs is to change their appearance to become another cancer that is similar, but insensitive to the drugs used
The experimental results showed that the transformation of malignant cells into macrophages involves profound changes in the chemical changes that take place in their messenger RNAs, the carriers that aid in the formation of proteins
Changes in the chemical properties of these molecules lead to the instability of the proteins that define leukemia, while promoting the emergence of differentiated proteins characteristic of macrophages in nascent normal cells
This line of research, although still in the preclinical stage, looks promising and deserves further exploration as a novel approach to combating leukemia
The more strategies that are developed, the better it will be for the thousands of patients diagnosed with hematological malignancies each year
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