By sticking cytokines to tumor tissue, "tumor adhesion" helps to fight cancer with precision

Researchers at the Massachusetts Institute of Technology in the United States have found that a special protein can "stick" cancer-fighting cytokines into tumor tissue like a "tumor adhesion" to enhance anti-cancer effectiveness, and it is expected that a new type of precision anti-cancer therapy will be developed in the future.The new study, published in the American Journal of Science Translational Medicine, shows that a protein called photoprotein polysaccharin can "limit" cytokines in solid tumor tissue, prolonging their time in killing tumors and reducing damage to healthy tissue.is a protein released by immune cells that works with other immunotherapy to fight cancer, but it kills both tumor tissue and normal body tissue. Oncologists had previously tried to inject cytokines directly into the tumor, but the protein "overflowed" after a few minutes.the researchers selected "white methylin-2" and "white methionin-12", two cytokines that stimulate the response of immune cells, and injected them into melanoma in mice. The results showed that mice could not survive with cytokines alone, that the survival rate of mice was slightly improved by combining cytokines with other immunotherapy, and that more than 90% of mice survived using cytokines combined with photoprotein polysaccharin and in combination with other immunotherapy therapies., lead author of the paper, said the synergies of these combination therapies, combined with the help of photoprotein polysaccharin, could make the most of the combined therapies. The team's next step is to try to apply this "tumor adhesion" to other anticancer therapies.
(News)