Brit J Cancer: The Role of Gender in The Congenital and Adaptive Immune Microenvironment of Metastatic Colorectal Cancer

Female patients with colorectal cancer (CRC) have a significant survival advantage over male patientsAlthough the immune response to CRC is important, the effect of gender on the tumor microenvironment (TME) is not yet clearIn a recent study published in the journal British Journal of Cancer, an authoritative journal on the field of oncology, researchers hypothesized that a different immune response from gender may help surviveresearchers used mouse models of metastatic CRC to assess local and systemic T-cells, macrophages, and cytokines, and to measure TME and serum cytokines using an array based on multiple magnetic beads, while using FCA to identify cells and phenotypesThe IHC provides morphological evidence of T-cell immersionfemale mice had increased survival and T-cell leachingPopulations of CD8, CD4 and Th2 were associated with longer lifetimes in miceSerum-towards-the-tendency factor sero-towards and inflammation-related cytokine levels increased in male miceIn TME, male mice had lower cytokine levels than female mice, and the peripheral cytokine gradient was smallerThe number of IL-10 plus macrophages increased in female tumors and was associated with survivalthese data demonstrate survival-related differences in the immune response of male and female mice to metastatic CRCFemale mice showed changes in cytokine production, along with an increase in the number of immune cells, in favor of Th2 phenotypesIn this model, the key differences in CRC immune response are related to survival ratesThese differences support a multifaceted shift across TME