Brit J Cancer: Relationship between antibiotic use and colorectal cancer risk.

There have been no studies to report a correlation between oral antibiotics and colorectal cancer (CRC) that varies with the antibiotic spectrum and colorectal cancer type, and whether there is a nonlinear dose-dependent relationship.
recently, researchers searched three electronic databases and a test platform for all relevant studies from the database until February 2020, without any restrictions, in a research paper published in British Journal of Cancer, an authoritative journal in the field of oncology.
the combined effect amount (ES) with 95% confidence interval (CI) was obtained from a meta-analysis of random effects.
dose-reaction modeling analyzed the relationship between antibiotic exposure days and CRC risk, and extended to nonlinear multivarivation random effect models.
6,483 published literature, 10 studies, including 4.1 million subjects and more than 73,550 CRC children, were eligible for inclusion.
increased risk of combined CRC in people who have used antibiotics (ES=1.17, 95% CI is 1.05-1.30), especially in people with broad-spectrum antibiotics (ES=1.70) 95% CI is 1.26-2.30), but not for narrow-spectrum antibiotic populations (ES=1.11, 95% CI is 0.93-1.32).
dose response analysis did not provide strong evidence of an association between any particular dose response, and the risk patterns for colon and rectal cancer were very similar.
the correlation between antibiotic use and CRC risk appears to vary between broad-spectrum and narrow-spectrum antibiotics.
is not clear whether this association has a causal relationship, and more mechanism studies are needed to further clarify the interaction between the drug and the microbiome.
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