Brit J Cancer: Anti-Acid Drugs and Colorectal Cancer Risk
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Last Update: 2020-06-25
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Source: Internet
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Author: User
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Although there are some reasonable biological mechanisms associated with the development of proton pump inhibitors (PPI) and H2 receptor antagonists (H2RAs) with colorectal tumors, their association withcolorectal cancer(CRC) risk has not been fully assessed in prospective epidemiological studies, researchers assessed the relationship between acid-suppressing drug use and CRC risk in 175,871 (PPI) and 208,831 (H2RA) participants from three large prospective cohort sishesesDrug use was assessed at baseline and updated every two yearsThe researchers evaluated the association using a multicox proportional risk regression modelthere is no significant correlation between baseline PPI use (risk ratio (HR) , 95% confidence interval (CI) 0.71-1.12) or after 8-10 years of delay (HR-1.12, 95% CI 0.78-1.59) and CRC riskThe researchers observed no significant correlation between 8-10 years after use of H2RA and CRC risk (HR s 1.02, 95% CI was 0.81-1.28), while baseline H2RA users had a lower risk (HR-0.76, 95% CI was 0.60-0.95)The duration of the use of PPI or H2RA is independent of CRC risk (trend P.21 and 0.95), it is not associated with a higher risk of colorectal cancer using PPI or H2RA
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