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For more than a century, the metabolism of cancer cells has been viewed as a sort of parado.
Glucose is a common sugar in food and one of the most important nutrients for the human bod.
However, there is a problem her.
Corresponding author Professor Gary Patti of Washington University School of Medicine in S.
Mitochondria are the body's energy factories, also known as the cell's powerhous.
"Now, we all know that's not tru.
"I think what's confusing is that it's been thought that cancer cells don't like oxidizing glucose in mitochondria," Patti sai.
Various explanations have been offered as to why cancer cells waste glucos.
Cancer cells do want to metabolize glucose in mitochondria, and they do, until they can'.
In other words, cancer cells waste glucose because NADH is transported too slowly to mitochondri.
"This is not a completely new metabolic paradig.
This research result was obtained through metabolomics technolog.
In this study, the researchers combined metabolomics with stable isotope tracer.
For decades, clinicians have used the rate at which tumors consume glucose to diagnose cancer and determine its stag.
"We may need to rethink how best to target glucose metabolism in cancer," says Patt.
Original text retrieval
Yahui Wang, Ethan Stancliffe, Ronald Fowle-Grider, Rencheng Wang, Cheng Wang, Michaela Schwaiger-Haber, Leah .