Brain? Stimul: Professor Sun Bomin gets new breakthrough in treatment of refractory anorexia nervosa

Anorexia Nervosa, commonly referred to as anorexia, is a severe eating disorder characterized by a reduction in spontaneous and persistent dietary intake caused by a self-perceived distortion of the body's shape and weightAnorexia can be classified as a restricted and bulimia-cleared type, based on the fifth edition of the American Diagnostic and Statistical Manual of Mental Illness , Fifth Edition, DSM-VAnorexia is also often associated with depression, anxiety, obsessive compulsive disorder and other mental illnessesTreatment of anorexia in adults is extremely difficult: there is no evidence-based medical evidence of the effectiveness of drug treatment;Professor Sun Bominpre-study results show that deep brain stimulation (Deep Brain Stimulation, DBS) of the Two-Sided Voltnucleus (NAcc) can be an effective surgical neuroregulation treatment for incurable anorexia, but a larger sample of follow-up cohort studies have confirmedrecently, the results of a forward-looking clinical study by Professor Sun Bomin's team were published onlineBrain Stimulation, an authoritative journal on neuroregulationProfessor Sun Bominto explore the safety, feasibility and effectiveness of the treatment of nAcc-DBSrefractory anorexiathe prospective study was designed to explore the safety and efficacy of NAcc-DBS in patients with refractory anorexia, focusing on the incidence and body mass index of complications associated with follow-up node surgery two years after surgery (Body Mass Index, BMI) improvement; the secondarystudies ended with 24 Hamilton Depression Scales (HAMDs), Hamilton Anxiety Scales (HAMA), Yale-Brown ForceD Scales (Y-BOCS), Social Functional Defect screening Scales (SDSS), and Simple Mental State Check Scales (MMSE)29 patients with refractory anorexia, 1 patient did not complete two years of follow-up due to non-medical factors, a total of 28 patients were included in the data analysis, including 13 patients with limited anorexia and 15 patients with bulimia removalPreoperative baseline BMI average 13.01 (SD 1.86) kg/m2safety, no deaths were reported in this study, but one patient had a rejection response to the stimulatorThe most common short-term adverse events associated with surgery are pain at the incision site (N -22), which usually disappears 3-4 days after surgeryNo serious surgical-related adverse events were recorded in this studyThere were no serious surgical complications such as intracranial hematoma, surgical incision infection, electrode shifting and fracturein terms ofeffectiveness, BMI improved significantly in the follow-up node in June after surgery, with an average BMI of 17.73 (SD 3.54) kg/m2 for two years after surgery, significantly better than the preoperative baseline levelIn terms of emotional co-sympathy, depression, anxiety and compulsive co-symtos also improved significantly in the two-year follow-up node after surgeryThe patient's social function score was significantly better than the preoperative baseline levelThe surgery had no significant effect on the patient's intelligence levelFurther post-mortem analysis showed that the Effect of NAcc-DBS was more significant in patients with simple restriction of anorexiaThis long-term follow-up study shows that NAcc-DBS is effective in treating incurable neurotic anorexiaAlthough NAcc-DBS appears to be more effective in patients with limited anorexia, strict surgical entry standards are required in view of potential surgical-related complicationsProfessor Sun Bomin has more than ten years of experience in the surgical treatment of anorexia nervosa, more than 300 cases of surgical treatment, the experience in this area is also more and more deep, including the grasp of patient indications, the choice of methods, the treatment of perioperative period, accumulated a wealth of experience The world's first report on neurotic anorexia brain deep electrostimulation treatment, and last year published the end-of-cystic forelimb damage treatment of refractory neurotic anorexia, a milestone, because it was in the United States Journal of Neurosurgery, but also damage surgery, because the industry has previously had some controversy over damage surgery, but the results and long-term follow-up surgery proved that the safety and effectiveness of surgery are very good Professor Sun Bomin believes that only mild anorexia is suitable for brain pacemaker (DBS), and moderate and severe anorexia nervosa, must consider damage surgery, because our aim is to cure the patient's neurotic anorexia and get a better quality of life