BRAIN: REM sleep behavior disorder and subsequent Parkinson's esomor

Idynic rapid eye movement sleep behavior disorder (RBD) is now considered α early manifestations of Synactal nucleoprotein disease.
increasing number of experimental studies have shown that manipulative lesions or neuron invigoration in the outer membrane nucleus (also known in humans as the small blue nucleus) can induce RBD-like behavior in animals.
Because current RBD animal models are not based on α-type synhapus nucleoprotein disease, they do not represent the pathological substrates of idiopathic RBD and cannot be modeled as esoteric transformations of Parkinson's disease.
therefore, the purpose of this study is to build an ANIMAL animal model based on α-synistan nucleoprotein disease, which has the potential to be converted to Parkinson's disease.
to this end, the researchers first identified the functional neuroanatomy location of the membrane nuclei under the outer epithirsty of the back in wild C57BL/6J mice, and then based on this determination the nuclei verified their function by outlining RBD-like behavior.
Next, pre-formed α-synth nucleoproteinogen fibers were injected into the lower core of the back side lid plate and routine polysomnia was recorded in these mice, as well as Parkinson's behavioral and tissue pathology studies.
results showed RBD-like behavior in mice and further showed that α-synaptic nucleoprotein disease and neuron degeneration, found in the outer side of the shoulder, were neuropathological substrates.
Subsequent Parkinson's behavioral studies showed that the RBD mouse model based on α synactin disease was not stable, but could be further developed to show Parkinson's motor dysfunction, depressive disorder, olfactory dysfunction, and gastrointestinal movement disorder.
accordingly, this study identified α-synactin pathology in the black-textured dense parts, olfactory glob, intestinal nerve plexus, and the motor nucleus of the ecstasy nerve back, which may be the basis for the performance of Parkinson's disease in mice.
in summary, this study established a new RBD mouse model based on α synactal nucleoprotein disease, and further demonstrated the esopid transformation of RBD to Parkinson's disease in this animal model.
Original Source: Yan Shen, Wen-Bo Yu, Bo Shen, MedSci Original Copyright Notice: All text, images and audio and video materials on this website that state "Source: Mets Medicine" or "Source: MedSci Original" are owned by Mets Medical, are not authorized, and may not be reproduced by any media, website or individual, and shall be authorized to reproduce with the words "Source: Mess Medicine".
all reprinted articles on this website are for the purpose of transmitting more information and clearly indicate the source and author, and media or individuals who do not wish to be reproduced may contact us and we will delete them immediately.
at the same time reproduced content does not represent the position of this site.
leave a message here