Brain: Relationship between local inflammatory cells and malignant multiple sclerosis

2020 May 16 News / BioValley BIOON / --- According to a recent study published in the "Brain" magazine, people with chronic multiple sclerosis (MS), brain, inflammatory cells into the brain through the blood longerInstead, these cells originated directly from the memory cells in the brainThe authors, colleagues NinaFransen and the Netherlands Institute for Neuroscience, illustrates thisMS neurological symptoms characteristic of the first system higher seizure frequency, and relatively good recoveryDuring the early onset disease, leukocyte migration with blood flow to the brain and causes inflammation in the brainIn patients with advanced MS, a neurological symptoms to reduce the number of attacks, but they have a disability developmentNinaFransen said: "Our previous studies have shown that there are still a large number of inflammatory activity in multiple sclerosis late brain." So the researchers wanted to know whether the white blood cells still play a role in inflammation of the late MS(Source: Www.pixabay.com)In this study, the authors focused on a particular type of white blood cells, namely T cellsMS patient examination by the late donated brain tissue, the researchers found a center in inflammatory lesions of activated T cellsThese cells have characteristic tissue resident memory T cellsThis T cell after viral infection remains in the organization, and provide long-term protection for new local infectionthese new findings support the concept: MS late in the disease occurs entirely inside the brainIn this case, the external impact of the disease is no longer white blood brainJoostSmolders explained: "These data provide insight into the disappointing results late MS currently treated by describing the behavior of T cells, we can start thinking about advanced methods to slow the disease process of MS patients.."suffering from to have MS in humans, is the cause of inflammation of the brain myelin (an insulating layer formed around the nerve) decompositionWithout this insulation layer of protection, the nerve cells can not properly exercise their functionsTherefore, including walking, feeling, speaking and thinking, etc., important functions affected(Biovalley Bioon.com)Information Source:LocalinflammatorycellsarecharacteristicforadvancedmultiplesclerosisOriginal source:NinaLFransenetal,Tissue-residentmemoryTcellsinvadethebrainparenchymainmultiplesclerosiswhitematterlesions,Brain < br /> (2020) .DOI: 10.1093 / brain / awaa117