BRAIN: Protein promotes Alzheimer's disease and age-related primary tauopathy brain atrophy

Alzheimer's disease is characterized by amyloid β and tau deposits in the brain, an increase in the rate of sea mass atrophy and sea mass atrophy over time.
another protein, TAR DNA binding protein 43 (TDP-43), has been found in up to 75% of Alzheimer's cases.
TDP-43, tau and amyloid β associated with sea mass atrophy.
TDP-43 and tau are also associated with tauopathy associated with primary age, and sea horse atrophy is a pathological feature that strongly overlaps with the characteristics of Alzheimer's disease and is associated with sea horse atrophy.
To this time, it is not clear whether TDP-43 and tau are associated with the early or late sea mass atrophy associated with Alzheimer's disease and primary age, and whether they are related to faster atrophy in other brain regions, and whether there is evidence of protein-related atrophy accelerating/deceleration.
therefore, this study aims to simulate how these proteins (especially TDP-43) affect the nonlinear trajectory of the age-related tauopathy between Alzheimer's disease and primary tauopathy and neoderal atrophy.
in this longitudinal retrospective study, 557 autopsy cases of neuropathological changes in Alzheimer's disease were analyzed and 1,638 pre-death volume head MRI scans were performed, with a pre-mortem course of 1.0-16.8 years.
the TDP-43 and Braak neurogenic fiber tangle pathology phased programs were constructed, and the brain capacity of the hippoclic and neothalal (lower and middle forehead lobes) was determined using vertical FreeSurfer.
used Bayes's double-variable results stratifle model to estimate the association between protein and volume, early atrophy rate, and acceleration of atrophy rate across brain regions.
TDP-43 stage is associated with a smaller cross-section of the brain more than a decade before death, an accelerated rate of brain atrophy and an accelerated rate of atrophy, and a deceleration tends to die.
is more correlated with the new cortical layer of the temporal lobe and frontal lobe.
, the low TDP-43 stage was associated with slower early morbidity, but with late acceleration.
later acceleration was associated with the tangle phase of high Braak neurogen fibers.
some similar but less obvious findings were observed between TDP-43 and the rate of the new cortical layer.
the Brack period appears to be more associated with the new cortical layer than TDP-43.
in patients with primary age-related tauopathy compared to Alzheimer's disease, the association between TDP-43 and brain atrophy occurred slightly later (about 3 years).
results show that TDP-43 and tau contribute differently to the acceleration and deceleration of the brain atrophy rate of Alzheimer's disease and primary age-related tauopathy over time.
original origin: Keith Josephs, Peter R Martin, Stephen D Weigand, Protein contributions to brain atrophy in Alzheimer's disease and primary age-related tauopathy Network Source: Web Copyright Notice: All text, images and audio and video materials on this website that state "Source: Met Medical" or "Source: MedSci Original" are owned by Mets Medicine and are not authorized to be reproduced by any media, website or individual.
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