On August 17, a study published in Cell Stem Cell, a journal of Cell Press, showed that human induced pluripotent stem cells (iPSCs) can be used to generate optic cups (a structure in the eye).
"Our work emphasizes the remarkable ability of brain organoids to produce primitive sensory structures, which are light-sensitive and contain cell types similar to those of the human body
Many aspects of human brain development and diseases can be studied with 3D brain-like organs derived from pluripotent stem cells.
But in the past, the use of pluripotent stem cells to derive optic cups was mainly for the production of retina
In order to achieve this goal, Gopalakrishnan and the team modified their previously developed solution for transforming iPSCs into neural tissue
Using 16 independent batches of iPSCs from 4 donors, the researchers generated 314 brain organoids, 72% of which formed optic cups, indicating that the method is reproducible
Gopalakrishnan said: "In the mammalian brain, the nerve fibers of retinal ganglion cells extend outward to connect with their brain targets, but this has never been demonstrated in an in vitro system
In future research, scientists plan to develop a strategy to enable the optic cup to survive for a long time, so as to study the mechanism of inducing retinal diseases
Related paper information: https:// href="https://" target="_blank">https://
This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only.
This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of
the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed
description of the concern or complaint, to
service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content
will be removed immediately.
