Brain: Millions of people in Denmark study: After multiple brain injuries, the risk of epilepsy is higher!

Brain trauma is a major global public health problem, affecting an estimated 69 million people worldwide each year.
TBI may continue to develop after initial rehabilitation, which can lead to persistent functional and neurological defects.
TBI is one of the main causes of epilepsy, and the risk of epilepsy after TBI peaks shortly after TBI occurs, but increases for many years after injury.
suggest that eclampsia and pathological mechanisms may evolve over years or even decades.
the severity of TBI injury is considered to be the most critical factor in the onset of epilepsy after TBI.
other known risk factors include sexuality, age at the time of injury, family history of epilepsy, and mental comorbidity.
in multiple TBI patients, some long-term neurological defects were more common than those in subjects who had only suffered TBI once.
suggests that repeated TBI may have cumulative effects.
pathology of the previous TBI may lower the convulsion threshold for epilepsy, which in turn makes subjects more prone to seizures after subsequent TBI.
contrary to expectations.
the cumulative effect of this repetitive TBIs on epilepsy risk is found in the available literature, although this may be due to a low rate of incidents and short follow-up times.
, however, the results of two recent animal studies suggest that repeated, mild TBIs and explosive injuries may be sufficient to cause seizures.
, the risk of epilepsy after repeated TBIs is unclear.
then, Kasper Lolk of Aarhus University in Denmark and others studied subjects born in Denmark between 1977 and 2016 based on registered queue study data to study the risk of epilepsy after the first and second TBI.
second goal is to study how this risk changes with TBIs time proximity, severity, and age.
, the study explores whether the risk of epilepsy after TBI changes due to gender, family history of epilepsy, and psychopathy.
they included 2476,905 people, using Cox and Competitive Risk Regression to estimate the cumulative risk ratio (HR) and post-brain epilepsy.
to estimate the cumulative rate of epilepsy in brainless trauma patients, they matched 10 control groups for each subject with brain trauma, matching the year of birth, sex, and date of brain injury of the target population.
, 167,051 subjects (71,162 women, 95,889 men) had brain trauma and 37,200 had epilepsy (17,905 women and 19,295 men).
compared to subjects without brain trauma, the relative risk of epilepsy after the first brain trauma increased (HR 2.04) and the second risk of post-brain trauma (HR 4.45).
increased with the severity of the first and second brain trauma, most noted after severe brain trauma.
women are more likely than men to develop epilepsy after mild brain trauma (HR 2.13 vs HR 1.77);
, the study's significance is to find that the risk of epilepsy increases decades after brain trauma.
these understandings can provide reference for the prevention of the development of epilepsy after trauma.
original source: Repeatedac brain injury and risk of epilepsy: a Danish nationwide cohort study; Kasper Lolk, Julie W Dreier, Jakob Christensen Brain, Freeman Source: MedSci Original Copyright Notice: All text, images and audio and video materials on this website that state "Source: Mets Medicine" or "Source: MedSci Originals" are owned by Mets Medicine and are not authorized to reproduce, and any media, website or individual authorized to reproduce them must indicate "Source: Mays Medicine".
all reprinted articles on this website are for the purpose of transmitting more information and clearly indicate the source and author, and media or individuals who do not wish to be reproduced may contact us and we will delete them immediately.
at the same time reproduced content does not represent the position of this site.
leave a message here