Brain immune memory affects the progress of neuropathy in mice

, according to a paper published online April
, the body's immune response affects the severity of brain disease later in life in mice through immune memory.
the innity immune system can retain infection "memory" for months, altering the subsequent immune response. There are two forms of immune memory: training to enhance the immune response against re-infection through training, and tolerance, and continuous exposure inhibits the immune response. Although inflammation in the body is known to stimulate the brain's immune response, it is not known whether immune memory occurs in the brain's inherent immune cells, small glial cells. The possibility of regulating the response of small glial cells, which are related to diseases such as Alzheimer's disease and stroke, has attracted widespread interest. In addition, they are extremely long-lived, so even if they are not permanent, lasting modifications are possible.
Jonas Neher of the German Center for Neurodegenerative Diseases and colleagues injected polysaccharies into mice with Alzheimer's models and found a significant increase in β-amyloid protein in the mice's brains. β-amyloid spot activates small glial cells, which are believed to ingest and process β-amyloid. After a single injection of lipid polysaccharies, small glial cells appear to have a training response. After 6 months, the mice received the injections accumulated more meso-amyloid β the controlled mice that did not receive the injections. However, after four injections, immune tolerance was developed and β-amyloid protein was reduced. Similarly, the authors found that immune tolerance reduced neuron damage after stroke. Study these processes or find new ways to alleviate neurological disorders. (Source: Feng Weiwei, China Science Journal)