BRAIN: Genetic, cellular and connective tissue characteristics of the brain regions common to gliomas?

For decades, it has been known that gliomas follow a non-random spatial distribution and occur more frequently in certain brain regions, such as the brain island, than in other regions, such as pillow leaves.
detailed understanding of glioma positioning patterns can provide clues as to the origin of these types of tumors, thus providing information for treatment targets.
based on previous studies of neuropsycological disorders and cancer, gliomas are expected to be located in brain regions characterized by the transcription of genetic drivers of functional hubs, stem cell-like cells and gliomas.
study combined neuroimaging data from 335 adult patients with high- and low-level gliomas to form a replicable tumor frequency map.
this graph, it is shown that the frequency of gliomas increases in the associated cortical layer and is related to multiple graph measurements of high functional connectivity.
regions of the brain made up of presumed cells of gliomas, neural stem cells and presumed cells of less protruding glial cells showed high glioma frequency.
using an ex post-gene expression map of the human brain, it was found that gliomas are located in the brain region, which is rich in gene expression associated with chromatin tissue and synact signals.
a group of glioma primary cancer genes were collected in the transcriptional group correlation of glioma distribution.
, regression models combining connective tissue, cells and genetic factors explained 58% of the risk of gliomas.
these results supplement previous literature on the vulnerability of the central region to neurological diseases, and also support the theory of cancer stem cells in gliomas.
the findings of this study illustrate how factors of different scales, from genetics to connectivity, independently influence the anatomical positioning of brain dysfunction.
origins: Ayan S Mandal, Rafael Romero-Garcia, Michael G Hart, Genetic, cellular, and connectomic characterization of the BRAIN regions commonly by glioma. MedSci Original Source: MedSci Original Copyright Notice: All text, images and audio and video materials on this website that indicate "Source: Mets Medicine" or "Source: MedSci Original" are owned by Mets Medicine and are not authorized to be reproduced by any media, website or individual, and are authorized to be reproduced with the words "Source: Mets Medicine".
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