Brain expert comment: How does air pollution make us dementia step by step?

Air pollution affects billions of people all over the world
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All types of combustion produce pollutants, including motor vehicles, power plants, residential wood burning and forest fires, so air pollution can be seen everywhere

Air pollution affects billions of people all over the world

2019 , Professor Kan Haidong, Fudan University School of Public Health, published in the world's top journal "New England Journal of Medicine" ( NEJM study on) would indicate, light micro air pollution is also associated with increased mortality

Including PM2.

Diana Younan is a senior research assistant in the Department of Preventive Medicine at the University of Southern California
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Her work is about the intersection of environmental health, neuroepidemiology, nutritional epidemiology, neuropsychology, neuroimaging and health difference research

Diana Younan is a senior research assistant in the Department of Preventive Medicine at the University of Southern California

More and more scientific evidence around the world shows that fine particulate matter, cognitive ability and Alzheimer's disease (AD) More and more scientific evidence around the world shows that fine particulate matter, cognitive ability and Alzheimer's disease (AD There may also be a link between) and related dementia

Recently, researchers used data from 998 women from the Women’s Health Initiative .
These women were between 73 and 87 years old and had two brain MRI examinations 5 years apart .
The researchers used a machine learning tool to score based on the similarity between the women’s brain MRI and gray matter atrophy patterns .
The higher the score, it indicates that the brain structure of women is more similar to that of AD patients .
They also collected the addresses of the women and built a mathematical model that allowed them to estimate the daily outdoor fine particle levels in the places where these women lived throughout the study period .

When the researchers combined all the above information, they found that there is a clear link between higher exposure to fine particulate matter, changes in brain structure, and memory capabilities, even before the symptoms of AD are manifested
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More precisely, fine particulate matter is related to brain gray matter atrophy (that is, the decrease of brain neurons)

When the researchers combined all the above information, they found that there was a clear connection between higher exposure to fine particulate matter, changes in brain structure, and memory capabilities, and even after they found higher exposure to fine particulate matter, changes in brain structure There is an obvious connection with memory ability, even before they found a higher exposure to fine particulate matter, changes in brain structure, and memory ability, there is an obvious connection, even before the symptoms of AD manifested

Further analysis found that the neuropathological phenomena of AD are considered to be the first to appear, and these changes are related to the decline of occasional memory performance

 "It appears that fine particulate matter is associated with an increased risk of AD and related outcomes," Diana Younan pointed out.

"This identifies a way that air pollution may be related to memory loss

 "It appears that fine particulate matter is associated with an increased risk of AD and related outcomes," Diana Younan pointed out.
"This identifies a way that air pollution may be related to memory loss

Although some risk factors for AD are unchangeable (such as age; heredity), some risk factors, such as environmental exposure, may be changed through life>
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Since there is currently no treatment for AD , it is becoming more and more important to determine the modifiable risk factors for the disease
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And air pollution seems to be such a risk
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references:

references:

https://blog.
oup.
com/2020/03/how-air-pollution-may-lead-to-alzheimers-disease/

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