BRAIN: Cross-frequency coupling of γ and deep brain stimulation frequencies in people with Parkinson's disease

It is generally believed that the destruction of pathologically enhanced β oscillation is considered to be one of the key mechanisms to mediate the clinical effects of deep brain stimulation on the motor symptoms of Parkinson's disease.
, however, specific regulations of other different physiological or pathological oscillation activities may also play an important role in symptom control and motor function recovery during deep brain stimulation.
finely tuned gamma oscillation has been recommended to have natural dynamics, which is conducive to the priority treatment of physiological and neural activity.
In this study, the researchers hypothesized that clinically effective high-frequency stimuli of the hypothyroidal nucleus would apply cross-frequency interactions with gamma oscillations in sub-cortical networks in interconnected regions and normalize the balance between β and gamma oscillations.
To this end, a high-density (256-channel) electroencephalogram of the stationary state was obtained from 31 patients with Parkinson's disease, who received deep electroencephalic stimulation and used beam-forming algorithms to compare the spectrum power and power-power cross-frequency coupling of the co-factors.
to show that modulation was only associated with the frequency of stimulation to relieve motor symptoms, two clinically ineffective frequencies were tested as control conditions.
study observed that strong decreases in β and increased power in areas of the cortical layer (motor cortical cortical layer, supplementary motor area, pre-motor pre-cortical layer) and sub-cortical network (subcrysta nucleus γ and cerum).
addition, a clear cross-frequency coupling between narrowband gamma frequencies and excitation frequencies was found in all these nodes, which was negatively related to motion disorders.
was not found in the area of the top leaf cortical layer after the control.
addition, deep electro-encephaloelectritis at clinically ineffective frequencies does not change the source power spectrum or cross-frequency coupling of any region.
these findings suggest that clinically effective deep brain stimulation of the hyalural core alters different oscillation activities differently in a wide network of subs cortical and subsurd areas.
, in particular, the cross-frequency interaction between fine-tuned gamma oscillations and stimulation frequencies may suggest a lighting mechanism that promotes dynamic neural processing for the mitigation of potential motor symptoms.
origin: Muthuraman Muthuraman, Manuel Bange, Nabin Koirala, Cross-frequency coupling between gamma oscillations and deep BRAIN stimulationy in Parkinson's disease. MedSci Original Source: MedSci Original Copyright Notice: All text, images and audio and video materials on this website that indicate "Source: Mets Medicine" or "Source: MedSci Original" are owned by Mets Medicine and are not authorized to be reproduced by any media, website or individual, and are authorized to be reproduced with the words "Source: Mets Medicine".
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