BRAIN: Carcinogenic effects of SRSF3

At present, glioblastoma is still the most deadly brain tumor, after diagnosis of survival of about 12-16 months.
, there is still an urgent need for new diagnostic strategies, prognosis and treatment tools to combat glioblastoma.
emerging evidence that the cellular mechanisms that control the shearing process (the shear body) change in the tumor, leading to cancer-causing shear events associated with tumor progression and invasiveity.
Here, for the first time, researchers have identified a serious imbalance in the expression of related shear components and shear factors (at mRNA and protein levels) in the well-characterized human advanced astroblastoma (mainly glioblastoma) cohort compared to healthy brain control samples.
SRSF3, RBM22, PTBP1, and RBM3 are perfect for the division of tumors and control samples, as well as neurosopathic or interstate tumors between glioma mouse models and control samples.
confirmed the results in four separate human queues.
SRSF3, RBM22, PTBP1, and RBM3 silence reduce in-body aggressive parameters (e.g. proliferation, migration, tumor ball formation, etc.) and induce apoptosis, especially SRSF3.
It is worth noting that SRSF3 is associated with patient survival and associated tumor markers, and its silence in the body may significantly reduce tumor development and progression through molecular/cell mechanisms involving PDGFRB and associated carcinogenic signaling path pathps (PI3K-AKT/ERK).
significant change in selective clipping events involving specific transcription factors that control PDGFRB (i.e. TP73).
results of this study suggest that intense molecular regulation associated with the shear mechanism has occurred in glioblastoma, which may be considered the source of new diagnostic and prognostic biomarkers for glioblastoma and therapeutic targets.
it is worth noting that SRSF3 is directly related to the occurrence, development, aggression and patient survival of glioblastoma and represents a new potential therapeutic target for addressing this devastating pathology.
origin: Antonio C Fuentes-Fayos, Mari C Vázquez-Borrego, Juan M Jiménez-Vacas, Splicing machinery dysregulation drives glioblastoma development/aggressiveness: oncogenic role of SRSF3. MedSci Original Source: MedSci Original Copyright Notice: All text, images and audio and video materials on this website that indicate "Source: Mets Medicine" or "Source: MedSci Original" are owned by Mets Medicine and are not authorized to be reproduced by any media, website or individual, and are authorized to be reproduced with the words "Source: Mets Medicine".
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