Brain, Behavior, and Immunity: How memory is maintained after brain damage

2020 May 13 News / BioValley BIOON / --- In a recent study, the authors of California at Riverside found that the impact of differences in TLR4 receptors on normal and injured brain and memory functionIn addition, the researchers discovered a new mechanism for how TLR4 regulation of normal, uninjured brain and memory functionThe study was conducted on rats, and published in "Brain, Behavior, andImmunity" magazine, could help develop treatments memory deficits after brain injuryassociate professor VijiSanthakumar The authors said: "The memory impairment is a major long-term consequences of brain injury, our research shows that, within the given drug treatment after the injury one day be able to achieve improved memory function, and therefore of great clinical significance." < br /> (source: Www.pixabay.com)present in brain neurons and non-neuronal cells called glial cellsIn normal brain, neuronal activity was suppressed TLR4In the injured brain, TLR4 activity will increase the strength of neuronsSpecifically, after a brain injury, TLR4 increase the excitability of the brain in the dentate gyrus of the hippocampus, the dentate gyrus and hippocampus is an important structure of memory processingstudy found that only neurons are involved in increasing the excitability of brain injury mediated by TLR4In contrast, glial cells decreased to normal brain excitability is mediated by TLR4 necessaryshe says: "We found that the inhibition of concussive brain injury after one day TLR4 signaling activity can reduce the excitability, and can improve working memory performance of one week to one month after our data show, may be selectively manipulatedthe potential damaging effects of brain damage in the process, and can remain in memory function after injury"
TLR4 in the end is not clear how it affects the normal and injured brain and memory functionSanthakumar said: "Although the actual mechanism is not clear, we speculate that TLR4 to regulate normal memory function by inhibiting the activity of neurons in the brain, thereby improving the signal to noise ratio." After the injury, TLR4 enhances neuronal activity and to promote the excitability, thereby increasing the discharge noise and non-specific neurons, and reduces the signal to noise ratioAfter the injury, TLR4 may impair the biological processes involved in memory formationThe most important thing is to suppress TLR4 signaling in the brain may be injured for several weeks to improve long-term memory deficits in a month (Biovalley Bioon.com) Information Source: Studyshowshowmemoryfunctioncouldbepreservedafterbraininjury Original source: AkshataA.Korgaonkaretal DistinctcellularmediatorsdrivetheJanusfacesoftoll-likereceptor4regulationofnetworkexcitabilitywhichimpactsworkingmemoryperformanceafterbraininjury, Brain, Behavior, andImmunity (2020) .DOI: 10.1016 / j.bbi.2020.03.035