BRAIN: Abnormal symposydroid dopamine in schizophrenia is structurally associated with cortical-pausc brain insemination

In patients with schizophrenia, dopamine abnormalities in the back stria and abnormal intrinsic functional connections (IFCs) between different cortical networks and the pasumosome are the most consistent large-scale brain imaging findings.
pathophysiological link between these two changes is proposed by theoretical models based on the topographic modulation of the cortical-basal nerve joint-hypothyroidal circuit endotrophic-hypothyroidism based on the synth dopamine.
We hypothesically assume that the abnormal symposome dopamine is toned to the terrain with the abnormal cortical-hypothetical iFC, i.e. the abnormal association staph dopamine is associated with the abnormal iFC between the significant network and the hypothyroid, and the abnormal iFC association between the abnormal sensory motor staph dopamine and the auditory-sensory device.
the study, 19 patients with schizophrenia and 19 age- and gender-like control subjects received both fluoxyhydroxybenzene-1-Alanine PET (18F-DOPA-PET) and resting-state function MRI (rs-fMRI).
18F-DOPA-PET-BASED tidal constant dissipator is used to measure the synthesis ability of the synthesized body dopamine.
coefficients between rs-fMRI time series of the cortogenic network and the regions of the desalcial brain of interest are used to measure iFC.
in a system centered on a significant network, the patient's synthesized dopamine synthesis was reduced, which was positively associated with a significant network-central-cerial iFC decrease.
this correlation is present in both patients and health control groups.
In a system centered on an auditory-sensory motor network, the patient's sensory motor synthesized dopamine synthesis was positively associated with an increase in the auditory-sensory motor network-abdominal cerum iFC.
this correlation exists only in patients.
results showed that the reduced strial dopamine synthesis ability was topographically associated with the inherent disassociation of the cortical-cerum brain in schizophrenia.
data show that the abnormal symposome dopamine and cortical-hypothyroidism in the dopamine-regulated cortical-basal nerve section-hypochoural circuit in schizophrenia are pathophysiologically related.
original origin: Mihai Avram, Felix Brandl, Franziska Knolle, Aberrant Striatal dopamine links topographically with cortico-thalamic dysconnectivity in schizophrenia. MedSci Original Source: MedSci Original Copyright Notice: All text, images and audio and video materials on this website that indicate "Source: Mets Medicine" or "Source: MedSci Original" are owned by Mets Medicine and are not authorized to be reproduced by any media, website or individual, and are authorized to be reproduced with the words "Source: Mets Medicine".
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