Br J Haematol: New discovery can lift the veil of athletes using blood doping

Red blood cell (RBC) transfusion is the most common treatment for hospitalized patients

Recently published in the of Haemotology British Journal magazine , a Duke University research team has found a way to help sports officials to detect whether or not the athlete's blood was injected into their own stored blood

Autologous blood transfusion is to take part of the athlete's blood before the competition, and only select the red blood cells, and then transfer these cells back to the athlete before the competition to improve the blood's ability to carry oxygen, and oxygen is an important fuel for muscle performance

Researchers study nucleic acids in red blood cells, especially RNA

The researchers took three units of blood from the volunteers and processed them to remove almost all white blood cells and approximately 80% of the plasma, leaving a relatively pure sample of red blood cells, just as required for autologous blood transfusion Like that

Increased expression of "miR-720" during red blood cell storage

Adding recombinant angiotensin to the stored rbc can further enhance the induction of "miR-720"

Angiotensin ( of angiogenin in ) promotes the storage of RBCs in miR-720 increased

These data indicate that red blood cell storage is associated with significant and reproducible "miR-720" induction

In the future, it will be of great interest to determine any functional role of highly expressed miR-720 in stored red blood cells as well as endothelial cells and macrophages

Article reference: Wen-Hsuan Yang, Jennifer Doss, Katelyn Walzer, Shannon McNulty, Jianli Wu, John Roback and Jen-Tsan Chi.