Br J Cancer: Tumor acidosis is associated with the metastasis potential of breast cancer

Breast cancer is the second leading cause of cancer-related deaths among women among the world.
metastasis of cancer remains the leading cause of death.
the past few years, the metastasis and mortality rates of breast cancer patients have decreased as a result of increased screening procedures and early diagnosis.
is thought to play a vital role in promoting cancer invasion and migration, but there is little research on the correlation between tumor pH and cancer invasiveness.
study aims to determine whether the acidity of tumors in the body is related to the metastasis potential of cancer.
the migration and invasiveness of TUBO, 4T1, and TS/A cells analyzed the metastasis potential of several breast cancer cell linees using aggressive and invasive tumor markers.
models of tumors in mice were constructed and lung metastasis evaluated, and tumor acidosis in the body was evaluated by chemical exchange saturation transfer (CEST) pH imaging based on magnetic resonance imaging (MRI).
4T1 and TS/A showed strong acidic tumor environment results showed that 4T1 and TS/A primary tumor cells had higher metastasis potential than tumor cells with less aggressive TUBO and BALB-neuT primary tumor cells than cancer cells, and the results were confirmed by the high expression of the dry markers of cancer cells (CD44-CD24-), corresponding to tumor migration and invasion tendency.
results are also consistent with in-body assays.
MRI-CEST pH imaging successfully distinguished more acidic 4T1 and TS/A tumors.
, the researchers observed a significant correlation between higher tumor acidity and an increase in lung metastasis.
, the results show that extracellular acidification is associated with the metastasis potential of cancer.
。