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Br J Cancer: TP53 mutation increases radiotherapy resistance of rhabdomyosarcoma and Ewing's sarcoma

 Last Update: 2021-06-01
 Source: Internet
 Author: User

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At present, the prognosis of patients with recurrent pediatric sarcoma (RMS) and Ewing's sarcoma (ES) is still very poor, and the long-term survival rate of patients is very low.

Although there is significant heterogeneity in the response of pediatric sarcoma after radiotherapy, it is currently unclear at the molecular level what drives the radiotherapy sensitivity and resistance of tumor tissues.

Further, the genomic determinants related to the response to liberation therapy are particularly important.

Previous studies have shown that p53 plays a key role in the DNA repair process and response to radiotherapy.

The researchers aimed to determine the TP53 mutation status and the related clinical phenotypes of p53 signaling pathway changes in RMS and ES patients undergoing radiotherapy.

Related research diagram

The results showed that the median follow-up time for patients was 26 months after radiotherapy.

Analysis of tumor progression and survival rate of radiotherapy in patients with different TP53 status

In summary, the results of this study indicate that TP53 mutations are associated with increased radiotherapy resistance in RMS and ES.

TP53 mutations are associated with increased resistance to radiation therapy in RMS and ES.

org/10.

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