Br J Cancer: Systematic assessment and meta-analysis reveal the role of immersive T-cell markers in the development of cervical cancer

Cervical cancer, one of the most common gynaecological tumors, has a high incidence and mortality rate globally, with more than 569,000 cases and 311,000 deaths in 2018.
While current screening among high-income people has significantly reduced the incidence of cervical cancer and will further reduce the incidence of the disease as vaccination programmes progress, differences in vaccination and routine screening have also led to significant differences in incidence.
infection with carcinogenic human papillomavirus (HPV) is one of the necessary causes of cervical cancer.
more than 90% of HPV infections are self-cleared within two years.
the host's adaptive immune response helps determine whether cervical HPV infection persists and develops into precancerog and cancer, while T-cell-soaked systemic symptoms help to understand key steps in the development of cervical cancer.
This study systematically evaluates and meta-analyzes insumptive T cells in normal cervical, low lesions, highly lesions, and immersive cancers, including endothyl, substation, and general tissue, as well as associated marker analysis: CD3, CD4, CD8, FoxP3, CD25, and CD4:CD8 ratios.
qualitative assessment summarized longitudinal data on the continuity, subsidion, development and prognostic correlation between immersive T cells and cervical disease.
flowchart researchers found that there were fewer CD3-plus, CD4-plus and CD8-plus cells in cervical lesions than in normal endocrine, and more cells in cancer.
In persistent and precancer lesions, FoxP3 and CD25 plus regulatory T-cells have high immersion rates, and longitudinal data show that lower regulatory T-cell levels improve the prognosis of patients.
The results show that successful immune escape can reduce HPV infection and T-cell immersion in precancer endocrine cells, while infusion cancer is highly immunogenic, and as cervical disease develops, the immersion of regulated T-cells increases.
conceptual model of indebted T-cells in the development of cervical cancer, understanding these factors has potential prognostic value and may provide some guidance for the development of new treatments and clinical guidelines.
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