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Br J Cancer: Phase II clinical study of pazopanib and topotecan in the treatment of patients with metastatic and unresectable soft tissue sarcoma

 Last Update: 2021-06-01
 Source: Internet
 Author: User

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Soft tissue sarcoma (STS) is a rare cancer that originates in mesenchymal tissue.

Angiogenesis is an established mechanism for the growth of malignant tumors including STS, and tumors have metastatic potential related to the degree of vascularization.

Recent studies have shown that pazopanib is active against refractory soft tissue sarcoma (STS) and can significantly prolong PFS in patients.

Patient's progression-free survival

This prospective, single-arm, phase II study mainly evaluated the efficacy of pazopanib and topotecan in the treatment of patients with metastatic or unresectable non-lipocytoma STS.

Patient's overall survival rate

The results showed that in the STS cohort, 57.

The combined treatment of pazopanib and topotecan is associated with grade 3 or 4 toxicity.

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