Br J Cancer: Multi-exercise reduces the risk of colorectal cancer

Colorectal cancer is one of the most common cancers in developed societies.
previous studies have shown that obesity is one of the risk factors for colorectal cancer.
high-calorie diet and sedentary lifestyle have made obesity a major public health problem in developed countries, further exacerbating the incidence of colorectal cancer.
observational epidemiological studies suggest that increased physical activity (PA) corresponds to a reduced risk of colorectal cancer.
and there is ample evidence of a protective link between recreational PA and colorectal cancer.
meta-analysis showed that occupational activities, recreational activities, transportation-related PA and occupational sedentative behavior were all associated with a lower risk of colorectal cancer.
Although there is strong evidence on the effects of PA on the risk of colorectal cancer, relevant observational studies cannot be attributed to this due to mixed factors or residual mixing.
, PA is usually measured as a self-reported form of activity in observational studies.
study was designed to investigate whether PA reduces the risk of colorectal cancer and to investigate the contribution of changes in body fat in the study, using Mendel Random (MR) studies.
common genetic variants associated with self-reported moderate to severe PA (MVPA), acceleration vector amplitude PA (AMPA) and sedentary time were used as tool variables in this study.
to control the mixed effects of obesity, the researchers included tool variables related to body mass index (BMI), body fat percentage, waist circumference, and fat ratios in arms, torso, and legs.
the role of these tool variables in the genome-wide association study of colorectal cancer, which included 31,197 cases and 61,770 controls, was analyzed through MR research.
(1-3) Forest Map reveals the risk correlation factors for colorectal cancer, showing that MVPA and AMPA reduced the risk of colorectal cancer by genetic measurements, which are mediated by genetic measurements of obesity.
the increased advantage ratio and 95% confidence interval (CI) per standard deviation of MVPA and AMPA are 0.56 (0.31, 1.01) and 0.60 (0.41, 0.88), respectively.
further studies showed no association between sedentation and the risk of colorectal cancer.
for MVPA and AMPA, the ratio of BMI mediated is 2% (95% CI:0,14) and 32% (95% CI:12,46), respectively.
BMI and body fat ratio assessment, the findings provide strong evidence for strengthening public health measures to prevent colorectal cancer, and the researchers recommend that, regardless of body fat status, promote the development of PA in the population or be beneficial in reducing the risk of colorectal cancer.