BMJ Sub-Journal: Study of Trauma and Depressive Symptoms in People at High Risk of Dementia in Middle Age

September 21, 2020 is the 27th World Alzheimer's Day, World Alzheimer's Day, with the theme "Let's talk about dementia" Chinese
, according to Alzheimer's Disease International, the disease affects 50 million people worldwide, with an average of three new cases of dementia occurring every three seconds.
In recent years, the number of Alzheimer's patients in China has ranked first in the world, according to incomplete statistics, the number of people with Alzheimer's disease has reached more than 8 million, an average of 300,000 new cases per year, and the prevalence rate with the increase of age, the number of cases is expected to reach 25% of the population in 2030.
Alzheimer's disease (AD), also known as Alzheimer's disease, was previously thought to be mutually exclusive with depression.
are called "false lesions" when depression and cognitive decline occur at the same time.
now, more and more studies have shown that depression is closely related to AD.
the prevalence of depression among older people with AD is reported to be about 50 per cent, well above that of the general elderly population (20-25 per cent).
, according to a meta-analysis based on a prospective population study, correcting the mixing factors increases the risk of dementia in older adults by 1.65 times in later life, and also increases the risk of developing from mild cognitive impairment to dementia.
Int J Geriatr Psychiatry. 2016 Aug; 31(8):905-11. doi: 10.1002/gps.4406. Depression and trauma are associated with changes in the brain regions involved in AD.
, a team from the University of Mon pillier in France assessed the relationship between childhood trauma, depression, adult cognitive function and the onset of dementia.
the results were published in the journal Journal of Neurology and Psychic.
researchers used data from the PREVENT dementia study of 378 people between the ages of 40 and 59.
the study were recruited through the Dementia Registry, the Dementia Joint Research Website, and research information from the Internet and research reports.
life-long trauma was assessed using a revised life stress checklist and a self-filled questionnaire containing 30 items was used to assess the age, risk and subsequent impact on daily life that had occurred in the past year.
use the Depression Scale (CES-D) to detect depressive symptoms.
use linear and logical models to assess the association between childhood trauma, depression, dementia risk, cognitive test scores, and sea mass volume.
results showed that 203 parents of the participants were diagnosed with AD, vascular dementia or mixed dementia.
of the 54 patients who experienced childhood trauma, 21 (38.9%) had a CES-D score of more than 16 or were currently undergoing treatment for depression.
childhood trauma and depressive symptoms were closely related to the decrease in the size of the sea mass, but not to current cognitive function or dementia risk.
people with a family history of dementia, the prevalence of depression was 25.6%, compared with 23.6% of people without a family history .
11.3 per cent of people with a family history of dementia reported childhood trauma, while only 17.8 per cent of people without a family history of dementia reported it.
further analysis found that the performance of delayed face/name meeting tasks was associated with depression.
childhood traumatic experience was still associated with decreased sea mass after controlling the possible effects of therapeutic factors on brain volume.
but poor cognitive performance are mainly associated with depression rather than differences in brain structure.
, the study suggests that depression may be associated with dementia in a number of ways.
future studies should consider the subsope of depression when studying the relationship between dementia and depression.
: Ritchie K, et al. Trauma and depressive symptomatology in middle-aged persons at high risk of dementia: the PREVENT Dementia Study. J Neurol Neurosurg Psychiatry. 2020 Oct 21:jnnp-2020-323823. doi: 10.1136/jnnp-2020-323823. MedSci Original Source: MedSci Original Copyright Notice: All text, images and audio and video materials on this website that indicate "Source: Mets Medicine" or "Source: MedSci Original" are owned by Mets Medicine and are not authorized to be reproduced by any media, website or individual, and are authorized to be reproduced with the words "Source: Mets Medicine".
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