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BMJ: Effects of plasma exchange in patients with ANCA-associated vasculitis

 Last Update: 2022-04-17
 Source: Internet
 Author: User

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In a study published in the top journal BMJ, researchers aimed to assess the impact of plasma exchange on important outcomes in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis
(AAV) .

Blood vessel

We conducted a systematic review and meta-analysis of randomized controlled trials that investigated the effect of plasma exchange in patients with AAV or pauciimmune
.

Researchers searched Medline, Embase and CENTRAL through July 2020

immunity

Meta-analyses used random-effects models to calculate hazard ratios and 95% confidence intervals
.

The quality of evidence was summarized according to the GRADE methodology

infection quality of life

The researchers included nine trials with 1060 participants who met eligibility criteria
.

Plasma exchange had no significant effect on all-cause mortality (relative risk 0.

CONCLUSIONS: For the treatment of AAV, plasma exchange had no significant effect on mortality, reducing the risk of ESKD at 12 months, but increasing the risk of serious infection
.

For the treatment of AAV, plasma exchange had no significant effect on patient mortality, reducing the risk of ESKD at 12 months, but increasing the risk of serious infection
.

Original source:

Michael Walsh, et al.

The effects of plasma exchange in patients with ANCA-associated vasculitis: an updated systematic review and meta-analysis Leave a comment here

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