BMJ: Differences in efficacy between different biological drugs in combination with methotrexate for rheumatoid arthritis
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Last Update: 2020-07-16
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Source: Internet
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Author: User
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!---- Recently, researchers conducted a systematic review and meta-analysis to assess the relative effectiveness of biological drugs in patients with rheumatoid arthritisresearchers collected the outcomeof outcomes of receiving the biological drug methotrexate treatment in human rheumatoid arthritis patients at least 24 weeks after they failed treatmentidentified 45 eligible trials and examined the effectiveness of 8 biological drugs and methotrexate combined applicationsanalysis showed no significant statistically significant differences in efficacy between combination therapy, but anaerhyleate had less benefit than almost all of the other seven biological drugs in terms of clinical remission or low disease activity (clinical disease activity index of 2.8 or 10, respectively), and the risk of cetozumab was greater than that of the other seven biological drugssome results have a very wide 95% confidence interval, which may mean unconfirmed differences between the eight biological drugs, but for low disease activity, severe adverse events, and infections, the 95% confidence interval is less pronouncedthe efficacy differences in the combined application of Janus kinase inhibitors could not be assessed due to the lack of head-to-head trialsstudy found that for patients with rheumatoid arthritis who failed to treat methotrexate, different biopharmaceuticals and methotrexate combinations differ only slightly in terms of benefits and harms
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